Enzyme oscillation

A third possible mechanism involves a transfer of phosphate from MgATP to the enzyme, followed by release of MgADP before the glucose hinds and picks up the phosphate Fig. 4-46). This type of mechanism is called Ping Pong because the enzyme oscillates between two stable forms, and F. The reaction sequence is ... 

Tsong TY, Liu D-S, Chauvin F. (1989). Electroconformational coupling (ECC) An electric field induced enzyme oscillation for cellular energy and signal transductions. Bioelectrochemistry and Bioenergetics 21 319—331. 

A comprehensive model of the hydrogel/enzyme oscillator will be complex, since it must take into account the presence and transport of several chemical species, and the distributed mechanical response of the hydrogel membrane. In an earlier analysis of the present system (21,22), a highly simplified, electromechanical relay-like model of the hydrogel was considered. This simple, heuristic model, lacked any elements of hydrogel physical chemistry or transport processes between the hyArogel and the reaction compartment (Cell II). 

The response of allosteric enzyme oscillator to a periodic and to a stochastic input of substrate has been investigated both experimentally [23, 24] and by numerical simulation. Experimentally, it is observed that pulses of ATP or ADP phases shift the oscillations where no such effect is observed with F6P and fructose-1,6-diphophate (FDP). This indicates the important role of adenylate control in the mechanism of glycolytic oscillation [21],... 

The earhest example of a membrane-enzyme oscillator was presented by Na-parstek, Caplan, and coworkers [52]. This oscillator consists of papain immobilized in a porous collodion membrane that is permeable to water, substrate, and ions. The membrane is cast as a thin film against a pH electrode and is exposed to an alkaline (pH 10) external solution of benzyl arginine ethyl ester (BAEE), which is a substrate... 

Leroux, J.-C. and Siegel, R.A. (1999) Autonomous gel-enzyme oscillator fueled by glucose-preliminary evidence for oscillations. Chaos, 9, 267-275. 

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