Enzyme multiple copper oxidases

Table 74 Multiple-type Copper Enzymes in Blue Oxidases...

Multiple Types of Copper in One Enzyme. When the blue copper oxidases were first investigated, attention naturally centered on the copper responsible for the intense blue color and the highly unusual ESR signal. Since both the unique optical and ESR parameters of the Cu(II) disappeared when the proteins were denatured, any more normal Cu(II) detected by ESR in these proteins was most often attributed to denatured enzyme (60). However, as more extensive studies on homogeneous samples of the blue copper oxidases were carried out, it became clear that... 

Fig. 38. Electron transport in P. aeruginosa, after reference 402. Multiple arrows represent multiple steps, possibly with undetected intermediates. Abbreviations Cu, copper-containing protein Oxid, oxidase enzyme. Dotted arrows indicate side reactions which perhaps are artifacts of extraction.

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