Environmental insult

The maintenance of the integrity of the information in DNA molecules is of utmost importance to the survival of a particular organism as well as to survival of the species. Thus, it can be concluded that surviving species have evolved mechanisms for repairing DNA damage occurring as a result of either replication errors or environmental insults. 

With very few short-term exceptions, these actions may lead hopefully to long-term improvement, largely by preventive measures, and by broad education of manufacturers, processors and users, to reduce health and environmental insults. How can such meaningful progress, if any, be measured, aside from numbers of regulations issued, or chemical compounds tested How can it be determined if this noble experiment is successful, let alone cost-effective M.J. Lipsett s paper suggests that impacts of TSCA on public and occupational health may take a long time to detect, if ever, simply because TSCA is only one in a spectrum of related laws. 

Nevertheless, there is strong evidence that some mental illnesses are partly inherited. One prevailing theory is the two hit hypothesis. The first of these two hits is a genetic trait that leaves one vulnerable to the illness. The second hit is some stressful life event or environmental insult (e.g., infection or toxic exposure) that triggers the onset of the illness in the vulnerable individual. 

Risk— A measure of potential economic loss, human injury or environmental insult in terms of the frequency of the loss or irqury occurring and the magnitude of the loss or injury if it occurs. 

Fetal and postnatal maturation of the nervous system need special mention, because the nervous system is the organ system that requires the longest time to mature. Outgrowth of neuronal processes, formation and deletion of synaptic contacts and myelination take place over an extended period of time in humans and laboratory animals. This extended maturation makes the brain susceptible to environmental insult for a long period. For example, adverse neurobehavioural... 

Porterfield SP. 1994. Vulnerability of the developing brain to thyroid abnormalities environmental insults to the thyroid system. Environ Health Perspect Suppl 102 125-230. 

The lakes have very different depths, and thus they have very different properties and responses to environmental insult. The depth profile of the lakes is shown in Fig. 2. 

To the extent that lipids are involved in corneocyte cohesion,36-39 the lipid structure in the outer SC is presumably very important for proper desquamation. However, because the outer SC interfaces with the surrounding environment, its lipids are the most susceptible to structural alterations caused by environmental insult or consumer products that often contain surfactants or solvents.5,12,30 While... 

A chemical plant complex used large volumes of brackish water from an adjacent river for once-through cooling. Occasionally, trace emissions of caustic soda were present in the effluent river water, and the company was concerned with pH excursions. An engineer was assigned to make modifications to reduce the opportunity of having environmental insults. 

For decades, most chemical manufacturers have employed a hierarchy of reviews, investigations, and reports for safety and environmental insults and incidents, ft is obvious that a Process Safety Incident Investigation is the highest level investigation that can incorporate other more limited investigations and reports. 

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