Environment neural crest cells

Thus, the interactions between cultured cells and their micro-environment that control the process of cell movement have, as their hub, an adhesive component. Manipulation of cell adhesion in tissue culture assays leads to predictable changes in cell movements. Could the complex process of neural crest cell migration in vivo also have an important adhesive basis First, in favorable in vivo situations where the dynamics of cell movement can be observed, the process of locomotion of crest-derived cells resembles that seen in the simplified cell culture models (see Newgreen,... 

Derby, M.A. (1978) Analysis of glycosaminogiycans within the extracellular environments encountered by migrating neural crest cells. Dev. Biol. 66 321-336. 

Sternberg, J. and Kimber, S.l. (1986) Distribution of fi-bronectin. laminin and entactin in the environment of migrating neural crest cells in early mouse embryos. J. Embryol. exp. Morphol. 91 267-282. 

The events governing these can be analyzed from the standpoint of what could inhibit them and how and in what sequence these inhibitions are lifted. The control of the timetable of the initiation of migration would then reside in the last inhibitory control. Four general categories of restraints can be recognized (i) physical barriers to migration in the environment of the crest cells (ii) compositional qualities unfavorable to migration in the environment (iii) locomotory incompetence in the crest cells (iv) inability of the crest cells to detach from the neural tube. 

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