Entropy biological macromolecules

Entropy is a measure of the order in a system Systems that are highly ordered have low entropies. The entropy of a molecule depends mainly on translational and rotational freedom. Biological macromolecules generally have much lower entropies than their building blocks. 

Although conformational control of synthetic macromolecules is a daunting proposition, given the enormous entropy cost that has to be borne, approaches to achieve this are being actively researched. Typically, synthetic polymer chains adopt a random coil conformation in solution, unlike biological macromolecules which... 

Stochastic thermodynamics describe small systems like biomolecules in contact with a well-defined heat bath at constant temperature and driven out of equilibrium. Based on an individual trajectory, stochastic thermodynamics formulates the first law and identifies entropy production (Seifert, 2012). Macromolecules of biological systems like proteins, enzymes, and molecular motors are embedded in an... 

It is clear that this concept defines critical needs regarding materials and methods. Mostly synthetic polymers were at the core, however, biological polymers and small organic molecules were also considered. The disadvantage of polymers often lies in their pronounced conformational flexibility demanding a high entropy prize upon supramolecular stmcture formation. Shape-persistent macromolecules have helped to overcome this drawback and have therefore defined one focus of the SFB. 

A similar postulate has been used by R.Fox [153] in order to prove the possibility of the anti-entropy processes during the formation of the biologically active macromolecules. 

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