Enterochromaffin-like cells proliferation

Enterochromaffin-like cell proliferation Thyroid toxicity... 

Modlin IM, Zhu Z, Tang LH, et al. Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia. Digestion 1996 57 310-321. 

Although mast cells and basophils probably account for >90% of stored histamine in the body, histamine is also present in platelets, enterochromaffin-like cells, endothelial cells, and neurons. Histamine can act as a neurotransmitter in the brain. Histaminergic nerves have their cell bodies within a very small area of the brain (the magnocellular nuclei of the posterior hypothalamus) but have axons in most areas of the forebrain. There is also evidence for axons projecting into the spinal (Fig. 1) cord. Finally, there is evidence that histamine synthesis can be induced in tissues undergoing rapid tissue growth and repair. In certain neonatal tissues (e.g. liver), the rate of synthesis of this unstored diffusable histamine (termed nascent histamine) is profound and may point to a role for histamine is cell proliferation. 

Katz LB, Schoof RA, Shriver DA (1987) Use of a five-day test to predict the long-term effects of gastric antisecretory agents on serum gastrin in rats. J Pharmacol Meth 18 275-282 Larsson H, Carlsson E, Mattsson H et al. (1986) Plasma gastrin and gastric enterochromaffin-like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 90 391-399... 

Larsson, H. et al. 1986. Plasma gastrin and gastric enterochromaffin like cell activation and proliferation. Gastroenterology 90 391-399. 

Tielemanns Y, Hakanson R, Sundler F, et al. Proliferation of enterochromaffin-like cells in omeprazole treated hypergastrinemic rats. 

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