Enteral feeds Warfarin

Potential tor reduced bioavailability because of complexation of drug with divalent and bivalent cations found in enteral feeding Decreased absorption of warfarin because of enteral feeding therapeutic effect antagonized by vitamin K in enteral formulations... [Pg.662]

Warfarin Decreased absorption of warfarin due to enteral feeding therapeutic effect antagonized by vitamin K content of enteral formulations Adjust warfarin dose based on INR Anticipate need to increase warfarin dose when enteral feedings are started and decrease dose when enteral feedings are stopped... [Pg.2631]

A number of early case reports described warfarin resistance in patients taking enteral feeds that contained high levels of added vitamin Kx- These products were then reformulated to contain lower amounts of vitamin Kx, commonly now about 4 to 10 micrograms per 100 mL however, some cases of interactions have still been reported, and one study in children reported that those receiving enteral nutrition (mostly vitamin K enriched formula) required 2.4-fold higher maintenance warfarin doses. Lipid emulsions containing soya oil might contain sufBcient natural vitamin Kx to alter warfarin requirements. Parenteral multivitamin preparations may also contain vitamin Kx. [Pg.406]

Martin JE, Lutomski DM. Warfarin resistance and enteral feedings. JParenterEnteral Nutr... [Pg.408]

Watson AJM, Pegg M, Green JRB. Enteral feeds may antagonise warfarin. BMI (1984) 288, 557. [Pg.408]

Penrod LE, Allen JB, Cabacungan LR. Warfarin resistance and enteral feedings 2 case reports and a supporting in vitro study. Arch Pl sMedRehabil (2001) 82,1270-3. [Pg.408]

In a prospective cohort study in 319 children, the use of enteral nutrition (mostly vitamin K supplemented formula, and some vitamin K supplemented tube feeds) was associated with a higher dose of warfarin to achieve a target INR (0.28 versus 0.16 mg/kg) and similarly a higher dose of warfarin was needed to maintain the INR (0.26 versus 0.11 mg/kg). ... [Pg.407]

Dickerson RN. Warfarin resistance and enteral tube feeding a vitamin K-indepen-dent interaction. Nutrition 2008 24(10) 1048-52. [Pg.730]

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