Enhancer enhanced regulation after

In my case the decisive period of experimentation that built into my brain the urge to clarify the unknown neurochemical mechanism of the acquisition of a drive fell between 1951 and 1953. After 50 years of continuous analysis of this problem, it has become my firm belief that the mammalian brain reached its highest level of organization with the evolution of specific cortical enhancer regulation enabling it to acquire drives. I also propose that this development culminated in the appearance of the Homo sapiens, the only mammalian species whose fife is primarily based on the acquisition of unnatural drives. It seems to me that just as the discovery of the force of mutual attraction among all bodies led to a sound interpretation of the world around us, the discovery of the force of mutual attraction between cortical neurons will lead to a sound interpretation of a brain function which is inseparable from conscious perception. 

Dozens of studies published since the proposal of this hypothesis have strengthened this approach step-by-step. The evolution of the project can be followed via the reviews published after 1982, when the original hypothesis was presented, until the discovery of mesencephalic enhancer regulation (Knoll 1983, 1985,1986a,b,c, 1989,1992a,b, 1993a, b,c, 1995,1998,2001,2003). 

Phosphorylation of HSF substantially enhances the transcriptional activity of HS gene expression which may be up to 100-fold of basal levels after HSFl binds to the promoter element. Heat shock will increase the C-terminal-domain-kinase activity in cell extracts, and this action may enhance the activity of RNA polymerase II that is bound to HS genes (Legagneux et al., 1990). Whether this kinase activity also affects HSFl phosphorylation is not known, but increased HS gene expression appears to occur as long as HSFl is bound to the promoter region. The CTD kinase complex contains multiple proteins, and it is quite possible that one or more of these proteins is also regulated by stress. 

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