Enhancement of Drug Solubility and Loading

As summarized in Table 15.1, CyDs are often formulated as inclusion complexes to significantly increase encapsulation of lipophilic drugs within microspheres, nanospheres, and lipidic vesicles. 

Most methods of nanosphere preparation described in the literature involve potentially toxic organic solvents, which are difficult to remove from the preparation media. Thus, methods using only aqueous media represent promising alternatives. Unfortunately, these techniques are not suitable for encapsulating large quantities of lipophilic molecules because of their poor solubility in water. 

The use of an inclusion complex instead of the free drug can also theoretically modify the drug localization within liposomes or niosomes. As a result, the included drug is predominantly incorporated within the aqueous core rather than in the lipid bilayer, changing its release profile. 

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