Energy metabolism lactate dehydrogenase

Fig. 5.4. Two types of energy metabolism in cestodes. (a) Type 1 homolactate fermentation, (b) Type 2 Malate dismutation. Reaction 3 involves a carboxylation step decarboxylation occurs at 6, 7 and 10. Reducing equivalents are generated at reactions 6 and 7 one reducing equivalent is used at reaction 9. Thus, when the mitochondrial compartment is in redox balance and malate is the sole substrate, twice as much propionate as acetate is produced. Key 1, pyruvate kinase 2, lactate dehydrogenase 3, phosphoenolpyruvate carboxykinase 4, malate dehydrogenase 5, mitochondrial membrane 6 malic enzyme 7, pyruvate dehydrogenase complex 8, fumarase 9, fumarate reductase 10, succinate decarboxylase complex. indicates reactions at which ATP is synthesised from ADP cyt, cytosol mit, mitochondrion. (After Bryant Flockhart, 1986.)...

The drug has high tendency to bind with various proteins and, therefore, may interfere with the energy metabolism, calcium transport and phosphorylation-dephosphorylation reactions [110]. Walter and co-workers [111-113] have found that suramin inhibits lactate dehydrogenase, malate dehydrogenase, malic enzyme and protein-kinase. Jaffe [114], showed that it also interferes with the folate metabolism of the helminths. 

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