6-Endotoxin oral toxicity

Table II. Oral toxicity of alkaline-solubilized BTI (Sandoz, Track 2) and BTK (Salsbury, Track 1) 6-endotoxin.

Kuhn, J. 1994. Acute Oral Toxicity Study in Mice CrylA(b) B.t.k. Delta-endotoxin Final Report Lab Project Number 1238/94. Unpublished study prepared by Stillmeadow, Inc. 20 p. 

Merriman, T. 1996. An Acute Oral Toxicity Study in Mice mih Bacillus thuringiensis subsp. kurstaki CrylA(c) Delta Endotoxin Lab Project Number DGC-95-A17 3406.1 S95.001.3406. Unpublished study prepared by DEKALB Genetics Corp. and Springborn Laboratories (SLI). 52 p. 

Shanahan, D. 1999. Supplement to MRID 44691101 Supplemental Data for Acute Oral Toxicity Study in Mice CrylF Bacillus thuringiensis var. aizawai Delta-Endotoxin Lab Project Number GH-C 5033. Unpublished study prepared hy Dow AgroSciences. 17 p. 

Chronic-Duration Exposure and Cancer. Several studies have examined the relationship between chronic exposure to ammonia and respiratory effects. Studies of farmers working in enclosed livestock facilities provide evidence that ammonia may contribute to transient respiratory distress (Choudat et al. 1994 Cormier et al. 2000 Donham et al. 1995, 2000 Heederik et al. 1990, 1991 Melbostad and Eduard 2001 Reynolds et al. 1996 Vogelzang et al. 1997, 2000) however, co-exposure to total dust, respirable dust, carbon dioxide, total endotoxins, respirable endotoxins, fungi, bacteria, and/or molds complicates the interpretation of these studies. A study of workers at a fertilizer production facility found an association between respiratory effects and ammonia exposure (Ballal et al. 1998). Another study did not find respiratory effects (Holness et al. 1989). Animal studies examining the chronic toxicity of inhaled ammonia were not identified. The human data were considered adequate for derivation of an inhalation MRL (Holness et al. 1989). No chronic-duration oral or dermal data were located. Studies by these routes of exposure would provide useful information on the identification of target organs especially after low-dose exposure. 

---