Endotoxin-induced uveitis

Jin, XH, Ohgami, K, Shiratori, K, Suzuki, Y, Hirano, T, Koyama, Y, Yoshida, K, Ilieva, I, Iseki, K, and Ohno, S, 2006. Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats. Invest Ophthalmol Vis Sci 47, 2562-2568. 

Suzuki, M., Noda, K., Kubota, S., Hirasawa, M., Ozawa, Y., Tsubota, K., Mizuki, N., and Ishida, S. (2010). Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. Mol. Vis. 16,1382-1388. 

Smith, J.R., Hart, P.H., Coster, D.J., Williams, K.A. Mice deficient in tumor necrosis factor receptors p55 and p75, interleukin-4, or inducible nitric oxide synthase are susceptible to endotoxin-induced uveitis, Invest. Ophthalmol. Vis. Sci. 1998, 39, 658-661. 

Behar-Cohen, F.F., et al. 1997. Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats. Exp Eye Res 65 533. 

Voigt, M., et al. 2002. Down-regulation of NOSH gene expression by iontophoresis of anti-sense oligonucleotide in endotoxin-induced uveitis, Biochem Biophys Res Commun 295 336. 

Miyamoto K, Ogura Y, Hamada M, Nishiwaki H, Hiroshiba N, Honda Y (1996) In vivo quantification of leukocyte behavior in the retina during endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 37 2708-2715. 

Brito BE, O Rourke LM, Pan Y, et al. Murine endotoxin-induced uveitis, but not immune complex-induced uveitis, is dependent on the IL-8 receptor homolog. Curr Eye Res 1999 19 76-85. 

Physically crosslinked HA hydrogel containing vasoactive intestinal peptide-loaded liposomes was developed for the treatment of endotoxin-induced uveitis. Interactions between HA chains and liposomes increased the viscosity of the gel and resulted in a delayed release of the vasoactive intestinal peptide [87]. However, the low stability of HA microparticles and physically crosslinked HA hydrogel is a limitation for protein delivery applications. 

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