Endoplasmic reticulum regulation

RBP is synthesized in the hepatocytes, where it picks up one molecule of retinol in the endoplasmic reticulum. Both its synthesis and its secretion from the hepatocytes to the plasma are regulated by retinol. In plasma, the... 

Stephens, S. B., Dodd, R. D., Brewer, J. W., Lager, P. J., Keene, J. D., and Nicchitta, C. V. (2005). Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. Mol. Biol. Cell 16, 5819—5831. 

The lipid compositions of plasma membranes, endoplasmic reticulum and Golgi membranes are distinct 26 Cholesterol transport and regulation in the central nervous system is distinct from that of peripheral tissues 26 In adult brain most cholesterol synthesis occurs in astrocytes 26 The astrocytic cholesterol supply to neurons is important for neuronal development and remodeling 27 The structure and roles of membrane microdomains (rafts) in cell membranes are under intensive study but many aspects are still unresolved 28... 

FIGURE 18-11 Regulation of neuropeptide expression is exerted at several levels. ER, endoplasmic reticulum LDCV, large dense-core vesicle TGN, trans-Golgi network. 

Riley, R. et al., Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognize rodent C YP3 A proteins and a similarly regulated human P450 enzyme(s), Biochem. Biophys. Res. Commun., 191, 32, 1993. 

Babiychuk EB, Draeger A 2000 Annexins in cell membrane dynamics. Ca2+-regulated association of lipid microdomains. J Cell Biol 150 1113-1124 Ber DM 2001 Excitation-contraction coupling and cardiac contractile force, 2nd edn. Kluwer Academic Publishers, Dordrecht/Boston/London Blaustein MP, Golovina VA 2001 Structural complexity and functional diversity of endoplasmic reticulum Ca2+ stores. Trends Neurosci 24 602—608 Flynn ER, Bradley KN, Muir TC, McCarron JG 2001 Functionally separate intracellular Ca2+ stores in smooth muscle. J Biol Chem 276 36411-36418 Fry CH, WuCl 997 Initiation of contraction in detrusor smooth muscle. Scand J Urol Nephrol Suppl 184 7-14... 

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