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Endoplasmic reticulum ceramide transport

Ceramide formed in mammalian systems is metabolized to sphingomyelin, glycosphingolipids, and ceramide 1-phosphate by the actions of sphingomyelin synthase, glucosylceramide synthase, and ceramide kinase on ceramide, respectively. Ceramide synthesized in the endoplasmic reticulum is transported to the Golgi apparatus for synthesis of complex sphingolipids (93). Sphingomyelin is synthesized from ceramide by transfer of the... [Pg.1767]

SIP is dephosphorylated by SIP phosphatases. The SIP phosphatase-1 isozyme decreases the transport of ceramide from the endoplasmic reticulum to the Golgi, as determined by the visualization of a fluorescent analog of ceramide that accumulates in the ER (98). SIP phosphatase type-2 is upregulated by inflammatory stimuli (99). [Pg.1768]

Y. Zhu, C. Vionnet, and A. Conzelmann, Ethanolaminephosphate side chain added to glycosylphosphatidylinositol (GPI) anchor by mcd4p is required for ceramide remodeling and forward transport of GPI proteins from endoplasmic reticulum to Golgi, J. Biol. Chem., 281 (2006) 19830-19839. [Pg.359]

Arab, S. and Lingwood, C., Intracellular targeting of the endoplasmic reticulum/nuclear envelope by retrograde transport may determine cell hypersensitivity to Verotoxin sodium butyrate or selection of drug resistance may induce nuclear toxin targeting via globotriosyl ceramide fatty acid isoform traffic, J Cell Physiol, 1998, 777 646 660. [Pg.1913]

See other pages where Endoplasmic reticulum ceramide transport is mentioned: [Pg.514]    [Pg.711]    [Pg.711]    [Pg.1770]    [Pg.218]    [Pg.378]    [Pg.379]    [Pg.414]    [Pg.570]    [Pg.573]    [Pg.389]    [Pg.199]   
See also in sourсe #XX -- [ Pg.471 ]



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