Endogenous endopeptidases

Because renal vasodilatation and hyperfiltration are often associated with a natriuretic response, a number of activators or inhibitors of endogenous vasoactive systems can cause increased NaCl excretion, and some of these may be developed into compounds of clinical interest in special situations. Such agents include natriuretic pqDtides most notably B-type natriuretic peptide (nesiritide), neutral endopeptidase (NEP) inhibitors (thiorphan, phosphoramidon), mixed NEP and ACE inhibitors (omapatrilat), guanylin and uroguanylin, kinins, prostaglandins of the E series, adrenomedullin, relaxin, prolactin, and others. 

Endogenous Antipyresis Endogenous Opioid Peptides Endometriosis Endopeptidase... 

Neprilysin (enkephalinase, Endopeptidase-24.11, neutral endopeptidase, NEP, EC 3.4.24.11) bears considerable resemblance to other zinc-containing metallopeptidases it is an oligopeptidase that hydrolyzes enkephalins and a range of other active peptides. Enkephalins are endogenous ligands of opiate receptors, and the prolongation of their action via inhibition of enkephalinase... 

The endogenous hormone atrial natriuretic peptide (ANP), which acts to increase blood pressure, is, like many other effector peptides, excised from a longer native chain by an endopeptidase enzyme, that is, an agent that cleaves bonds well along the chain of amino acids. A small-molecule endopeptidase inhibitor lowers blood pressure by inhibiting the release of ANP. The inhibitor candoxatril (6-8) is now... 

Aside from gastrointestinal and renal metabolism, the liver may also contribute substantially to the metabolism of peptide and protein drugs. Proteolysis usually starts with endopeptidases that attack in the middle part of the protein, and the resulting oligopeptides are then further degraded by exopeptidases. The ultimate metabolites of proteins, amino acids and dipeptides, are finally reutilized in the endogenous amino acid pool. The rate of hepatic metabolism is largely dependent on specific amino acid sequences in the protein. 

Encron rizolipasc. endogenous pyrogen > interleukin-1. ENDOPEPTIDASE INHIBITORS act at one or other of the endopeptidase enzymes that cleave the C-terminal residue from oligopeptides or proteins (thus are stricdy proteinases). They can be divided into classes on the basis of their functional characteristics. These classes are dealt with separately in terms of their alternate names, notable substrates and inhibitors. They often act along with ectopeptidases - the carboxypeptidases and amino-peptidases. Endopeptidase inhibitors contain members of the metalloproteinase and serine protease families. Some are important neuropeptidases - concerned with degradation of... 

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