Endogenous drugs

Goh LB, Spears KJ, Yao DG, Ayrton A, Morgan P, Wolf CR and Friedberg T (2002) Endogenous Drug Transporters in In Vitro and In Vivo Models for the Prediction of Drug Disposition in Man. Biochem Pharmacol 64 pp 1569-1578. 

Other Endogenous Drug Lead Platforms Carbohydrates, Nucleic Acids... 

The evidence from this laboratory and from others reviewed in this chapter reinforces and extends the serious concern that external contamination of hair by drugs of abuse can easily occur. Any interpretation of hair analysis data should consider the prospect that the sample could have been externally contaminated. The pharmacokinetics of the incorporation of drugs into many tissues has been well elaborated. However, substantial additional information on the mechanisms for incorporation of drugs into hair, the decontamination of hair, the differentiation between exposure to exogenous and endogenous drugs, and the meaning of the presence of metabolites in the hair are needed before hair analysis can be employed in many forensic applications. 

Drug Intake Required to Produce Hair Drug Levels at the Cutoffs Set as Protection against Passive Endogenous Drug Exposure "... 

As a final consideration, the possibility of the presence of non-specific binding of drugs by plasma proteins and the specific binding by endogenous drug-specifrc antibodies should be borne in mind when unexpected results are obtained from an immunoassay. 

Endogenous drugs Drugs produced within the body. 

Synthetic drugs Diugs created by chemists in laboratories, as opposed to endogenous drugs or semi synthetic drugs. 

M6. Mabuchi, H., and Nakahashi, H., Isolation and characterization of an endogenous drug-binding inhibitor present in uremic serum. Nephron 44, 277-281 (1986). 

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