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Endogenous cellular defense mechanisms

Cellular defense mechanisms against toxins (A multistep mechanism for elimination of toxic metabolites and xenobiotics. It involves various transport, oxidation, and conjugation steps.) are usually divided into several steps as it is visualized on Fig. 3. Organic anion transporting proteins (OATPs) are responsible for the cellular uptake of endogenous compounds and... [Pg.750]

Redox signaling might play an important role in RPE cell functions. Lower levels of oxidative stress may evoke endogenous cytoprotection. In addition, redox signaling may also affect other important cellular functions. However, if the cellular defense mechanism is unable to effectively deal with ROS, the cells undergo apoptosis... [Pg.57]

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