Endocannabinoids receptors

After the discovery of specific endocannabinoid receptors, the amount of scientific literature quickly rose and not only new potential indications were established, but also the mechanisms for the already known effects were clarified. Although the most prominent effect of C. sativa is clearly related to THC and its activity at the CBl receptor, most other natural cannabinoids are not active there. Today two other natural cannabinoids CBD and THCV are the focus of medicinal research. 

Benzinou M, Chevre JC, Ward KJ et al (2008) Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body... 

Looking ahead, we hope that this review may stimulate scientists with an interest in endocannabinoid signalling to exploit not only the familiar mammalian model species (rats, mice) but also the rich diversity of non-mammalian animals where the existence of endocannabinoid receptors has been established. 

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