Encoding Methods for Solid-Phase Pool Libraries

4 ENCODING METHODS FOR SOLID-PHASE POOL LIBRARIES 

Structure determination of positives from SP pool libraries can also be made through the coupling of a tag, or code, that will unequivocally encode the structure of the library component to each library individual. These tags may be divided in two classes chemical tags, which are compounds with a completely different chemical nature from the library compounds, and nonchemical tags, which use nonchemical entities to code for all the library structures. 

The tags are often used as binary-coded mixtures, as shown in Fig. 7.24 for a hypothetical example where six tags are available. Using tags to code individually for 

A family of chemical tags should ideally possess a number of features. It should be stable to all, or to the large majority, of the reaction conditions that may be used in an SP hbrary synthesis its synthesis should be easy and almost quantitative using commercially available precursors its presence should not interfere with the library synthesis scheme it should be inert in library screening when on-bead methods are used its structure should be determined with a fast and reliable method. We will now present the various chemical encoding strategies reported in the hterature and will comment on their fulfillment of the above criteria. 

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ENCODING METHODS FOR SOLID-PHASE POOL LIBRARIES 303 INDIVIDUAL CODES ... 

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