Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons

ENANTIOSELECTIVE SYNTHESIS OF PROPARGYL ALCOHOLS AS MULTIFUNCTIONAL SYNTHONS 

Indian Institute of Chemical Technology Hyderabad, India 

The science of organic synthesis revolves around the development of newer strategies and methodologies which are more efficient, greener, practical, and safe. Despite the fact that there has been dramatic success in the past few decades in the area of development of newer and environmentally friendly methods, one is not able to synthesize everything that is needed. In fact, in the literature there are more unconquered complex targets than already synthesized targets. There are several complex bioactive and most wanted natural products that are either conquered but not with optimum efficiency or that have never been synthesized.  

Drug Discovery and Development, Volume 2 Drug DevelopmerU, Edited by Mukund S. Chorghade Copyright 2007 John Wiley Sons, Inc. 

Before venturing into describing various strategies developed for the synthesis of propargyl alcohols in optically pure form, it would be interesting to look at various bioactive natural products and derivatives synthesized starting from this multifunctional 

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