Enantiomeric Separation Without Using a Chiral Source

Host rac-Cuest Distillation times repeated Chiral product  

Enantiomeric Separation Without Using a Chiral Source 

Enantiomeric separation of some compounds can be accomplished by complexa-tion with achiral compounds. Some examples are described below. 

Enantiomeric Separation of roc-7-Bromo-l,4,8-triphenyl-2,3-benzo[3.3.0]octa-2,4,7-trien-6-one 

The title compound (107) [42] has been found to form inclusion complexes with a wide variety of solvent molecules [43]. In the complexation, racemates or conglomerates of 107 were formed, depending on the choice of solvent. In the latter case, the inclusion crystals consisting of one enantiomer of 107 were formed preferentially and the enantiomeric separation of 107 could be performed. For example, recrystallization of rac-107 from the solvents shown in Table 3.3-10 gave a 1 1 complex of the rac-107 with the solvent as yellow crystals. On the other hand, recrystal-lization of the rac-107 from the solvents shown in Table 3.3-11 gave a 1 1 complex 

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Enantiomeric Separation Without Using a Chiral Source M 7 7... 

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