Glibenclamide Enalapril

Slc22a7) Drugs NSAIDs, AZT, MTX, zalcitabine Drugs p-lactam antibiotics, NSAIDs, bumetanide, enalapril, glibenclamide, rifampicin, verapamil... 

A 67-year-old man using glucocorticoids for asthma, ranitidine 300 mg/day, and enalapril 5 mg/day developed a low blood glucose (1.2 mmol/ 1) within 48 hours of starting to take glibenclamide 5-10 mg/day. 

Parlapiano C, Paoletti V, Campana E, Giovanniello T, Pantone P. Increased risk of hypoglycemia from enalapril plus ranitidine with glibenclamide a clinical case. Adv Ther 1999 16 130-2. 

A 72-year-old man with diabetes mellitus and cardiovascular disease developed major depression. He was taking aspirin (100 mg/day), enalapril (20 mg/day), and glibenclamide (5 mg/day). His serum sodium was 133 mmol/1 (reference range 134—146 mmol/1). He started to take reboxetine (4 mg/day) and after 8 days experienced malaise and nausea, at which time his serum sodium had fallen to 118 mmol/1. The reboxetine was withdrawn, and both his symptoms and the low serum sodium remitted over the next 6 days. Rechallenge with reboxetine produced a recurrence of both the low sodium and the accompanying symptoms. 

Oat2 Benzylpenicillin, erythromycin, tetracycline, rifampicin, glibenclamide, tolbutamide, zidovudine, ganciclovir, digoxin, enalapril, verapamil, methotrexate, acetylsalicylic add... 

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

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