Empty sella syndrome

Empty sella syndrome occurred in a boy who developed hypopituitarism after long-term pulse therapy with prednisone for nephrotic syndrome (107). 

Two patients developed hypopituitarism and empty sella syndrome during glucocorticoid pulse therapy for nephrotic syndrome (SEDA-22, 444 118). 

A partial empty sella syndrome occurred in an elite 39-year-old body-builder with a 17-year history of drug abuse involving growth hormone, anabolic steroids, testosterone, and thyroid hormone (82). 

The pituitary is a hormone-responsive gland, but it has not previously been shown to suffer negative feedback in response to any of these substances. Any one of them could in principle have contributed to the effect, or it could have been an indirect consequence of drug abuse, by way of an increase in intracranial pressure, which is a known cause of empty sella syndrome. 

Dickerman RD, Jaikumar S. Secondary partial empty sella syndrome in an elite bodybuilder. Neurol Res 2001 23(4) 336-8. 

Partial empty sella syndrome (pituitary atrophy) has been described in an elite body builder who had abused various hormones, including testosterone, growth hormone, and triiodothyronine 25 micrograms qds for many years (56). He presented with infertility, and investigations showed suppression of serum TSH, a raised serum T3, and a partially empty pituitary sella. 

Empty sella syndrome has been reported in 4% to 16% of patients with amenorrhea and galactorrhea. ... 

Kamoda T, Nakahara C, Matsui A. A case of empty sella after steroid pulse therapy for nephrotic syndrome. J Rheumatol 1998 25(4) 822-3. 

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