Emesis, antagonists radiation-induced

It had been reported that 5-HT and 2-Me-5-HT released DA in striatal slices [112]. The functional importance of this response is unknown, because the D2-dopamine antagonists are not efficient antiemetics against radiation- or chemotherapy-induced emesis. 

The 5-HT3 antagonists, such as ondansetron and granisetron, have found clinical utility in the treatment of emesis, particularly for radiation or chemotherapy-induced cases [46], Application to post-surgical and other forms of emesis are less well documented. S-HT, receptors have also been speculated to be involved in cognition, anxiety, migraine, and pain. However, clinical proof of their role in these states is still lacking. 

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