Emericella unguis

From a marine isolate of the fungus Emericella unguis collected in Venezuelan waters, an antibacterial depside, guisinol (118), has been isolated. It is active against Staphylococcus aureus [94]. 

Nielsen J, Nielsen PH, Frisvad JC (1999) Fungal Depside, Guisinol, from a Marine Derived Strain of Emericella unguis. Phytochemistry 50 263... 

Recently, a total synthesis of the moderately antibacterial unguisin A (1219) was reported (789). This naturally occurring cyclopeptide from Emericella unguis possesses an unusual y-butyro acid residue contained within the macrocycle. Its total synthesis, a combination of solid phase and solution chemistry, is outlined in Scheme 15.4. 

Kawahara N, Nozawa K, Nakajima S, Kawai K-I (1988) Isolation and Structures of Novel Fungal Depsidones, Emeguisins A, B, and C, from Emericella unguis. J Chem Soc Perkin 1 2611... 

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