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Ellipticine and related alkaloids

Fig. 8.5. Separation of ellipticine and related alkaloids, isolated from mouse blood Column"yBondapak C18 (300x4.0 mm ID), protected with a precolumn (50x4.6 mm ID) packed with a 40 urn pellicular material, mobile phase acetonitrile - 0.01 M sodium dihydrogen phosphate (1 3)(pH 3.5 with 2 N phosphoric acid), flow rate 1.4 ml/min, detection UV 300 nm. Peaks 1, ellipticine 2, 9-hydroxyellipticine 3, 11-demethylellipticine (internal standard). Fig. 8.5. Separation of ellipticine and related alkaloids, isolated from mouse blood Column"yBondapak C18 (300x4.0 mm ID), protected with a precolumn (50x4.6 mm ID) packed with a 40 urn pellicular material, mobile phase acetonitrile - 0.01 M sodium dihydrogen phosphate (1 3)(pH 3.5 with 2 N phosphoric acid), flow rate 1.4 ml/min, detection UV 300 nm. Peaks 1, ellipticine 2, 9-hydroxyellipticine 3, 11-demethylellipticine (internal standard).
Ellipticine inhibits DNA, RNA and protein synthesis. The inhibition is not reversible by removal of the alkaloid. It has no appreciable effects on thymidine and uridine kinases or on RNA polymerase, but it markedly inhibits DNA polymerase activity [240, 241]. The actual mechanism of action of ellipticine and related compounds has not yet been elucidated. Ellipticine and derivatives have been found to interact with bacterial membranes [242]. Many investigators have categorized these compounds as DNA-interacting or intercalating agents [230, 235, 237,243-246]. It has recently been postulated that mammalian DNA topoisomerase II may be a common target of these antitumour compounds [247],... [Pg.51]

Cepheranthine and related bis-isoquinoline alkaloids (AA) michellamine B and related isoquinoline alkaloids (AA) chelerythrine and related benzophenanthridine alkaloids (AA) ellipticine and related indole alkaloids (AA)... [Pg.8]

Ellipticine and related quaternary alkaloids have been analyzed on an octadecyl column using heptane- or pentanesulfonate as pairing-ion (see Chapter 8, Tables 8.5 and 8.6). [Pg.426]

Ellipticine, uleine, apparicine, and related alkaloids 01MI37. [Pg.175]

Details of the synthesis of ellipticine and related pyridocarbazole alkaloids by Gilbert et al. have now been published. "... [Pg.175]

Protein kinase A (PKA) Ellipticine and related indole alkaloids... [Pg.7]

Gribble GW (1990) Synthesis and antitumour activity of ellipticine alkaloids and related compounds. The Alkaloids, Chemistry and Pharmacology (ed Brossi A) Vol 39. Academic, San Diego, pp 239-352. [Pg.401]

SYNTHESIS AND ANTITUMOR ACTIVITY OF ELLIPTICINE ALKALOIDS AND RELATED COMPOUNDS... [Pg.239]

See other pages where Ellipticine and related alkaloids is mentioned: [Pg.359]    [Pg.414]    [Pg.291]    [Pg.262]    [Pg.428]    [Pg.380]    [Pg.392]    [Pg.342]    [Pg.262]    [Pg.382]    [Pg.359]    [Pg.414]    [Pg.291]    [Pg.262]    [Pg.428]    [Pg.380]    [Pg.392]    [Pg.342]    [Pg.262]    [Pg.382]    [Pg.168]    [Pg.360]    [Pg.8]    [Pg.51]    [Pg.828]    [Pg.272]    [Pg.182]    [Pg.30]    [Pg.175]    [Pg.234]    [Pg.346]    [Pg.240]    [Pg.241]    [Pg.243]    [Pg.245]    [Pg.249]    [Pg.251]    [Pg.255]    [Pg.257]    [Pg.259]    [Pg.261]    [Pg.263]    [Pg.265]    [Pg.267]    [Pg.269]    [Pg.271]    [Pg.275]    [Pg.279]    [Pg.281]    [Pg.283]    [Pg.285]   
See also in sourсe #XX -- [ Pg.39 , Pg.239 ]



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