Ellagic acid aspartic protease

A number of plant natural products have been isolated that inhibit an aspartic protease secreted by Candida albicans [35, 36], the most potent of which (IC50 values 8-14 pM) are the phenolics ellagic acid [35] and mattucinol-7-0-[4",6"-0-(5)-hexahydroxydiphenoyl]-P-glucopyranoside [35] and the triterpene betulinic acid [36] (Table 1). A macromolecule from Anchusa is a potent inhibitor of pepsin (K 20 nM) [37] (Table 1). 

Ellagic acid (polyphenol) Widespread, ellagitannin product Fragaria spp. (Rosaceae) Candida albicans secreted aspartic protease (11 pM) Pepsin (37 pM) [35]... 

---