Electrospray Mass Spectrometry ESMS Analysis

In view of the powerful nature of the Pt2S2 core to couple to virtually all metals in the Periodic Table, and because different metals can carry a range of functionalities, there is an infinite number of possible permutations that one can attempt. It is therefore important to develop a combinatorial-like tool which can be used 

11 (a) M. Capdevila, Y. Carrasco, W. Clegg, R. A. Coxall, P. Gonzalez-Duarte, A. Lledos, 

Department of Inorganic Chemistry, Politehnica University Bucharest, Polizu 1, 78126-Bucharest, Romania 

The synthesis of the first divalent metal complexes of squarate ion (C404) by West and Niu in 1963, has constituted the starting point for many researches of the coordination chemistry of squarate dianion. 

In the light of the structures of squarate-metal complexes reported so far it is clear that chelation by this ligand is limited to some alkaline- and rare-earth metal cations. This behaviour is explained by the large bite parameter of squarate dianion. 

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Electrospray mass spectrometry has developed into a well-established method of wide scope and potential over the past 15 years. The softness of electrospray ionization has made this technique an indispensable tool for biochemical and biomedical research. Electrospray ionization has revolutionized the analysis of labile biopolymers, with applications ranging from the analysis of DNA, RNA, oligonucleotides, proteins as well as glycoproteins to carbohydrates, lipids, gly-colipids, and lipopolysaccharides, often in combination with state-of-the-art separation techniques like liquid chromatography or capillary electrophoresis [1,2]. Beyond mere analytical applications, electrospray ionization mass spectrometry (ESMS) has proven to be a powerful tool for collision-induced dissociation (CID) and multiple-stage mass spectrometric (MSn) analysis, and - beyond the elucidation of primary structures - even for the study of noncovalent macromolecular complexes [3]. 

Racaityte K, Lutz ESM, Unger KK, Lubda D, Boos KS. 2000. Analysis of neuropeptide Y and its metabolites by high-performance liquid chromatography-electrospray ionization mass spectrometry and integrated sample clean-up with a novel restricted-access sulphonic acid cation exchanger. J Chromatogr A 890 135. 

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