Electrospray ionization—tandem mass spectroscopy

Chen, X.-L. et al.. Direct observation of a series of non-covalent complexes formed by phosphor-ylated flavonoid-protein interactions through electrospray ionization tandem mass spectroscopy. Anal Chim. Acta, 511, 175, 2004. 

Charrouf, Z. et al.. Separation and characterization of phenolic compounds in argan fruit pulp using liquid chromatography-negative electrospray ionization tandem mass spectroscopy. Food Chem., 100, 1398, 2007. 

Kamel AM, Zandi KS, Massefski WW. 2003. Identification of the degradation product of ezlopitant, a non-peptidic substance P antagonist receptor, by hydrogen deuterium exchange, electrospray ionization tandem mass spectrometry (ESI/MS/MM) and nuclear magnetic resonance (NMR) spectroscopy. J Pharm Biomed Anal 31 1211. 

It was not possible to use MS for the characterization and identification of chlorophylls and its derivatives until the development of desorption methods (desorption ionization) appropriate for nonvolatile and thermolabile compounds. The mass spectmm of chlorophylls has been obtained using laser desorption [92-94], field desorption [95], plasma desorption [96,97], fast atom bombardment (FAB) [28, 98-101], in-beam electron ionization [102], and electrospray ionization (ESI) [103]. A combination of the techniques of desorption and tandem mass spectroscopy (MS/MS) has also been used for the charactmzation of chlorophylls and derivatives [ 104—107]. The latest research in this field coupled HPLC with MS, using as ionization source FAB [108-110] or atmosphoic pressure chemical ionization (APCI) [111-115]. 

HPLC High liquid chromatography, ED electrochemical detector, ESI electrospray ionization, MS tandem mass spectrometry, LPT Liquid-phase sorbent trapping, TD Thermal desorption, GC Gas chromatography, TLC Thin layer chromatography, DAD Diode Array, FD Fluorescence detection, FTIR Fourier transform infrared spectroscopy, SPME Solid phase microextraction... 

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