Electrospinning silk fibroin nanofibers

Min, B.M., et al., 2004. Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro. Biomaterials 25 (7-8), 1289-1297. 

However, electrospinning of a mixture of silk fibroin and inorganic ceramics, such as hydroxyapatite, is still a challenging task. The mechanical properties of electrospun silk fibroin scaffolds can be enhanced by uniformly dispersing hydroxyapatite nanoparticles within silk fibroin nanofibers. Hydroxyapatite nanoparticles were modified by y-glycidox q3ropyltrimethoxysilane for uniform dispersion and enhanced interfacial bonding between hydroxyapatite and silk fibroin fibers. 

In order to improve the properties and the spinnability, fibroin sometimes has been electrospun together with other natural or synthetic polymers (Jin et al., 2002 Park et al., 2004, 2006 Wang et al., 2004, 2006). For instance, Jin et al. (2002) developed an aqueous process for silk electrospinning in combination with PEO. More recently, Cao (2008) used PVA/Silk Fibroin (SF), Gelatin/SF, and Hydroxyapatite (HAP)/SF to produce double-layered (core-shell) nanofibers (mats) by coelectrospinning. 

An electrospinning process was used to fabricate silk fibroin (SF) nanofiber nonwovens for wound dressing applications. The electrospinning of regenerated silk fibroin (SF) was performed with formic acid as a spinning solvent For ciystallization, as-spun SF nanofiber nonwovens were chemically treated with an... 

Optimal conditions for electrospinning of silk fibroin and y-glycidoxypropyltrimethoxysilane modified hydroxyapatite nanoparticles to achieve beadless nanofibers without any aggregation of hydroxyapatite nanoparticles could be identified. 

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