Electrophoretic microchip technology

AN INNOVATIVE SEPARATION PLATFORM ELECTROPHORETIC MICROCHIP TECHNOLOGY... 

Microchip technology (see Ref. 454 and Fig. 17) is revolutionizing chemical and biochemical testing. The microchip processes fluid rather than electrons. Both electrophoretic and electroosmotic techniques are used to pump the fluid. Pumps, valves, volume-measuring devices, and separation systems are on the microchip s surface. Microchip separation procedures include electrophoresis, chromatography and solid-phase biochemistry. Microchips allow true parallelism, miniaturization, multiplexing, and automation, and these key features provide a set of performance specifications that cannot be achieved with earlier technologies (64-68,454-463). 

Castillo, M. A., and Vargas, M. G, Development of capillary electrophoretic methods for bovine milk quality control, Presented at the 12th Latin-American Symposium on Biotechnology, Biomedical, Biopharmaceutical and Industrial Applications of Capillary Electrophoresis and Microchip Technology, Queretaro, Mexico, 2-5 December, 2006. 

Zhao, X.C., You, T.Y., Qiu, H.B., Yan, J.L., Yang, X.R., and Wang, E.K., Electrochemilmninescence detection with integrated indium tin oxide electrode on electrophoretic microchip for direct bioanalysis of lincomycin in the urine. Journal of Chromatography B—Analytical Technologies in the Biomedical and Life Sciences, 810, 137-142, 2004. 

It is likely that alternative sequencing technology will displace electrophoretic sequencing. Microfabricated capillary array electrophoresis has been studied for human identification via STRs. Genetic analysis by PCR has been reported for prenatal diagnosis of beta-thalassemia. Microchip devices can automate the complete DNA analytical process, including DNA extraction, cleanup, PCR, and size separation." ... 

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