Electronic tongues inhibition

Cortina, M., del Valle, M., and Marty, J.-L. (2008). Electronic tongue using an enzyme inhibition biosensor array for the resolution of pesticide mixtures. Electroanalysis 20(1), 54-60. 

RNA aptamer specifically binding and inhibiting the activity of the catalytic ricin A-chain (RTA) has been selected [57]. Initially 80 nucleotides long, it has been shortened to 31-nucleotide aptamer that contained all sequences and structures necessary for interacting with RTA. Inhibition properties of this aptamer exceeded known ricin inhibitors. This aptamer along with others was used to develop a multispecific sensor. Aptamers were immobilized on beads, introduced into micromachined chips on the electronic tongue sensor array, and used for the detection and quantification of proteins. The lowest detected ricin concentration using this sensor was 1 pM (320 ng/mL) [58]. 

Valdes-Ramirez G, Gutierrez M, del Valle M, Ramirez-Silva MT, Fountier D, Marty JL (2009) Automated resolution of dichlorvos and methylparaoxon pesticide mixtures employing a Flow Injection system with an inhibition electronic tongue. Biosens Bioelectron 24... 

Alonso GA, Dominguez RB, Marty J-L, Munoz R (2011) An approach to an inhibition electronic tongue to detect on-line organophosphorus insecticides using a compute controlled multi-commuted flow system. Sensors ll(4) 3791-3802... 

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