Electronic effect on the destabilization of carbonyl and

4 Electronic effect on the destabilization of carbonyl and imono groups 

The instability of the carbonyl group of perfluorinated ketones and aldehydes suggests, in other words, its high reactivity toward nucleophiles. The more reactive carbonyl groups react with nucleophiles much faster than do the less electrophilic ones. Trifluoromethylated ketones are more reactive to nucleophiles. Thus, a Diels-Alder reaction of cyclopentadiene 

The strong electrophilic nature of the trifluoroacetyl group functions as a key functional group in potent inhibitors for serine proteases, which have attracted a great deal of attention as therapeutic targets. The idea is based on the effective trapping of a serine hydroxyl group 

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