Electrochemical sensors with MIPs

I Chiral Electrochemical Sensors Based on MIPS with Pharmaceutical Applications... 

As it has been shown, basically all chiral MIP-based electrochemical sensors were developed up till now for amino acids or monosaccharides. However, chiral pharmaceuticals present more complex structures compared to the already mentioned molecules thus, their efficient molecular imprint is considered to be more difficult. Moreover, in the case of amino acids, the asymmetric carbon is at the molecule s extremity carrying two functional groups (-NH2 and -COOH) strongly interacting with the used common functional monomers, thus easily leading to highly enantiospecific imprinted cavities. 

MIP-based tramadol sensing devices include the highly selective MWCNTs carbon paste electrode modified with molecularly imprinted polymers with differential pulse voltammetric detection. The device had a linear response range of 10 to 10" M [350]. The other report was on an MIP-electrochemical sensor prepared by coating SiO, Fe O, as the core and the supporting material, with an MIP based on ethyleneglycol dimethacrylate as the crosslinker and functional monomers. The MIP-modified particles prepared this way were eventually incorporated into the modified carbon paste electrode, which was used for cyclicvoltammetry of the analyte within a linear range of 0.01-20 pmolL-i [366]. 

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