Chiral Electrochemical MIP-Based Sensors

Although molecular imprinting has more than six decades of history [4], MIPs were introduced in electrochemistry only in 

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I Chiral Electrochemical Sensors Based on MIPS with Pharmaceutical Applications... 

As it has been shown, basically all chiral MIP-based electrochemical sensors were developed up till now for amino acids or monosaccharides. However, chiral pharmaceuticals present more complex structures compared to the already mentioned molecules thus, their efficient molecular imprint is considered to be more difficult. Moreover, in the case of amino acids, the asymmetric carbon is at the molecule s extremity carrying two functional groups (-NH2 and -COOH) strongly interacting with the used common functional monomers, thus easily leading to highly enantiospecific imprinted cavities. 

In order to really prove the versatility and real analytical potentials of MIP-based chiral electrochemical sensors, in the near future their performance also toward more complex chiral molecules ought to be demonstrated so they could overcome the laboratory scale barrier. 

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