Electrochemical sensors metallocenes

Electric arcs, in metal vapor synthesis, 1, 224 Electric-field-induced second harmonic generation Group 8 metallocenes, 12, 109 for hyperpolarizability measurement, 12, 107 Electrochemical cell assembly, in cyclic voltammetry, 1, 283 Electrochemical irreversibility, in cyclic voltammetry, 1, 282 Electrochemical oxidation, arene chromium carbonyls, 5, 258 Electrochemical properties, polyferrocenylsilanes, 12, 332 Electrochemical reduction, bis-Cp Zr(III) and (IV) compounds, 4, 745 Electrochemical sensors biomolecule—ferrocene conjugates... 

Studies of synthetic porphyrin-based anion receptors should form the basis for more effective sensors. Metallocene-substituted porphyrins examined by Beer and coworkers have proven successful in the solution-phase binding of ions such as chloride, bromide and nitrate." The cobaltocenium-substituted and ferrocene-substituted porphyrins (Figure 134) bind ions in solution, as shown by H NMR and electrochemical studies. The latter measurements reveal that the porphyrin and ferrocene redox... 

Ferrocenylated ODNs were first immobilized in a self-assembled redox-active monolayer on Au electrodes by Letsinger and co-workers.Upon hybridization of a complementary strand, the electrochemical potential of the ferrocene changes. In addition to applications as electrochemical DNA sensors, such self-assembled DNA monolayers with electro-active groups may provide information on the mechanism of electron transfer through DNA, and indirectly also on molecular mobility within short stretches of DNA. " We have recently extended this idea by the use of immobilized metallocene-labeled PNA on Au electrodes. Because PNA is an uncharged molecule, a surface with improved properties forms, and electrochemical detection, also of single mismatches, is facilitated. 

It will be interesting to follow the development of surface-bound electrochemical protein sensors based on metallocene-peptide conjugates. 

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