Electrochemical Investigations of Metachromasia

Because of the possibility of ion association and charge transfer the use of conductometric titration is suggested. Preliminary unpublished conductometric studies by the authors on the reaction between bromophenol blue and quaternary ammonium and arsonium salts failed, within the sensitivity of the instrument used, to detect any conductivity changes. The reaction is, however, accompanied by metachromasia and can be followed spectrophotometrically, showing again the complementary nature of the physical methods available. 

Thomas, Drug Interactions, in Drugs/Actions and Uses. Selected Review Articles, No. 1, New Ethicals, Sydney (1969). 

Melville and C. Johnson, Cured to Death. The Effects of Prescription Drugs, Angus and Robertson, London (1982). 

Monitoring for Drug Safety, MTP Press, Lancaster (1980). 

Australian Pharmaceutical Handbook and Formulary, 13th edition. The Pharmaceutical Society of Australia, Canberra (1983). 

---