Elderly population screening

Can some important questions concerning development and clinical use of this drug in the elderly be answered by a population screen approach or will specific elderly study subject trials be required ... 

For prevention of disease in the elderly, the pregnant, or other susceptible groups, national fortification of food with vitamin B12 appears sensible and inexpensive but at present is not used and, in the absence of population screening s unlikely to be mandated by governmental edict. In general terms, the hematological manifestations of vitamin B12 deficiency are rapidly and fully correctable, although deficiencies of other micronutrients such as iron, folic acid, pyridoxine, copper, or vitamin C may be unmasked in the process and may limit the bone marrow s response until they are also corrected. 

The indications for CTC closely follow the indications for conventional optical colonoscopy with few exceptions. These indications include screening asymptomatic high- and average-risk patient populations, pre-operative assessment of the colon proximal to an obstructing mass, evaluation of patients with change in bowel habits, surveillance of patients post colorectal cancer surgery, and incomplete or failed colonoscopy. Patients with bleeding diathesis, contraindications to sedation, and frail and elderly patients may also be better suited for CTC than conventional colonoscopy. 

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