Eicosanoid in amphibians

Amphibians differ in three important ways from mammals with respect to synthesis of eicosanoids (i) they have EPA as a natural substrate, and thus can potentially produce 3-series prostaglandins and 5 series leukotrienes without dietary supplementation (ii) nucleated erythrocytes and thrombocytes produce cyclooxygenase and lipoxygenase products endogenously and (iii) synthesis of eicosanoids is regulated, at least in part, by environmental temperature. These differences impact the actions of eicosanoids in the cardiovascular system of amphibians. 

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