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Pharmacodynamics efficiency

Desensitization describes the rapid signal attenuation in response to stimulation of cells by receptor agonists. Changes in the coupling efficiency of receptors to signal transduction pathways and receptor internalization can account for desensitization and the development of pharmacodynamic tolerance. [Pg.1204]

RNAi has had an important impact on the development of novel disease models in animals, and it is likely that siRNAs, the trigger molecules for RNA silencing, will become an invaluable tool for the treatment of genetic disorders. The rational design of siRNAs, the introduction of chemical modifications into siRNAs to improve their pharmacokinetic and pharmacodynamic properties for in vivo application with high specificity, and the development of efficient delivery system will foster the therapeutic application of RNAi in AD and other neurodegenerative disorders (413,417). [Pg.270]

Alvan G, Paintaud G, Wakelkamp M. The efficiency concept in pharmacodynamics. Clin Pharmacokinet 1999 36 375-89. [Pg.178]

Insulin Diabetes Human (18 type-I diabetic patients) Inhalation (AERx ) Pharmacodynamic system efficiency 12.7%. Dose-response relationship close to linear [64]... [Pg.210]

See other pages where Pharmacodynamics efficiency is mentioned: [Pg.69]    [Pg.247]    [Pg.68]    [Pg.176]    [Pg.229]    [Pg.35]    [Pg.448]    [Pg.455]    [Pg.185]    [Pg.213]    [Pg.334]    [Pg.338]    [Pg.2]    [Pg.91]    [Pg.225]    [Pg.173]    [Pg.516]    [Pg.101]    [Pg.717]    [Pg.652]    [Pg.268]    [Pg.280]    [Pg.77]    [Pg.369]    [Pg.6]    [Pg.161]    [Pg.11]    [Pg.227]    [Pg.244]    [Pg.198]    [Pg.238]    [Pg.668]    [Pg.85]    [Pg.447]    [Pg.305]    [Pg.55]    [Pg.349]    [Pg.315]    [Pg.22]    [Pg.285]    [Pg.2674]    [Pg.2802]    [Pg.2807]    [Pg.1503]    [Pg.2627]   
See also in sourсe #XX -- [ Pg.165 ]



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Pharmacodynamic

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