Effervescent ibuprofen

The bioavailability of an effervescent ibuprofen tablet was compared to a sugar-coated tablet. Ibuprofen was absorbed more rapidly from the effervescent tablet but both formulations were bioequivalent in... 

EFVDAS Effervescent drug absorption Ability to incorporate high drug Ibuscent (Ibuprofen) as an... 

Effervescent compositions of ibuprofen, another analgesic, are marketed. 

Altomare, E. Wendemiale, G. Benvenuti, C. Andreatta, P. Bioavailability of a new effervescent tablet of ibuprofen in healthy volunteers. Eur. J. Clin. Pharmacol. 1997,52,505-506. 

There are at least theoretical solutions to these two problems. The large volume is less of a problem in dosage forms such as instant or effervescent granules of ibuprofen [505], while the use of large quantities of solvents can sometimes be avoided by using a solvent-free production process such as the roll-mixing process for triturations. 

Katare OP, Vyas SP, Dixit VK. Effervescent granule based proliposomes of ibuprofen. J Microencapsul 1990 7 455-62. 

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