Effects on the Protection of Neuronal Cells

Another interesting property of HA pharmacology relates to a broad range of protective actions. It has been smdied that HA could protect neuronal cells against nerve gas 

HA also protects primary neuronal cell culture and animals from glutamate toxicity. Glutamate activates A-methyl-D-aspartate (NMDA) receptors and increases the flux of calcium ions into the neurons,whereas calcium at toxic levels can kill the cells. Pretreatment of primary neuronal cells with HA reduced glutamate- and OP-induced toxicity and decreased neuronal death.The consequence of excitatory amino-acid-induced overstimulation has been implicated in a variety of acute and 

---