Effects on Membrane Aggregation and Fusion

Other lines of evidence also point towards a fusogenic capacity of SMase. Holopainen et al. [142] showed microscopic images of endocytic budding of vesicles 

The activity of one enzyme was affected by its own reaction products and by substrates and products of the other enzyme. These authors concluded that the mutual lipid-mediated interfaclal modulation between both phosphohydrolytic pathways indicated that phospholipid degradation might be self-amplified or dampened depending on subtle changes of surface pressure and composition. 

The authors are grateful to the Ministerio de Ciencia y Tecnologia (grant no. BMC2001-0791) and the Universidad del Pals Vasco (grant no. 13552/2001) for continuing support. The assistance of Dr M.I. Collado with the reaction mechanisms is greatly appreciated. 

Newrzella, D. and Stoffel, W., Biol. Chem. Hoppe Seyler, 1992, 373, 1233-1238. 

27 Grassme, H., Jekle, A., Riehle, A., Schwartz, H., Berger, )., Sandhoee, 

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