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Effects of Vincristine on the PNS

The detailed molecular mechanism of neuropathic pain caused by repeated systemic injection of vincristine is poorly understood. In general, systemically injected vincristine poorly penetrates into the CNS because of the blood—brain barrier (BBB) (Calabresi and Parks, 1985). It is thought that vincristine may act on [Pg.181]

Lymphocytes and leukocytes also infiltrate into the injured region after nerve injury (Morin et al., 2007 Thacker et al., 2007). It was demonstrated that T-cells infiltrated into the injured nerve at the same time or before macrophage infiltration, and promoted macrophage chemotaxis (Kleinschnitz et al., 2006). There are no reports showing lymphocyte infiltration in the PNS after [Pg.182]


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