Effects of Silica Nanomaterial Properties on Toxicity

In in vivo studies, the induced toxicity of silica nanomaterials is transient, with the level of apoptosis, neutrophil and macrophage counts andcytokine/chemokine expressions returning to normal between one week and one month of recovery. 

Many factors influence the toxicity of sUica nanomaterials, including their size, shape and surface and core properties, as well as the concentration of the nanomaterial, the treatment time and the type of targeted cell line. Thus, a knowledge of these factors might help in the reduction and/or control of the toxicity associated with sihca nanomaterials. 

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