Effects of Growth and Development

Growth of a tissue implies an excess of protein synthesis over degradation and can be produced by changes in the rate constants for either pathway. As a result of the technical difficulties in measuring protein 

Relative Contribution of Changes in ka to Alterations in Enzyme Content 

The change in enzyme content from one steady state to another can be analyzed in terms of the individual changes in kg and ka at the two steady states. This is accomplished according to equation (2) from measurements of any two of E, ka, and kg. 

As mentioned in the discussion on enzyme changes during development, the most efficient and rapid way to alter enzyme content would be to change both kg and k. This is seen with the changes in hepatic 

The values in Table 5 are at steady states. During the transition from one steady state to another there can be transient but dramatic changes in either kg or For example, refeeding starved rats decreases the synthesis rate for hepatic phosphoenolpyruvate carboxykinase to 

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