Effects of Chronic Tobacco Use

Clearly, the addictive power of cigarettes is directly related to their nicotine content. It is not known to what extent nicotine per se contributes to the other well-documented adverse effects of chronic tobacco use. It appears highly probable that nicotine contributes to the increased risk of vascular disease and sudden coronary death associated with smoking. Also, nicotine probably contributes to the high incidence of ulcer recurrences in smokers with peptic ulcer. 

Nicotine s Dependence Liability Effects of Chronic Tobacco Use Tar, Nicotine, and Carbon Monoxide Diseases Linked to Cigarette Smoking Other Tobacco Products and Health Passive Smoking... 

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