Effects of anti-oxidants on post-traumatic neurological recovery

Effects of anti-oxidants on post-traumatic neurological recovery 

In addition to demonstrating the occurrence of acute post-traumatic oxygen radical reactions and their association with pathophysiological events, the establishment of their importance, relative to other factors, is ultimately dependent upon a demonstration that by interrupting them, chronic neurological recovery can be enhanced. Thus, attempts have been made to show that early treatment of spinal-cord injured animals with bonafide antioxidants or agents with antioxidant properties can beneficially affect sensory and motor recovery. 

High-dose pretreatment with vitamin E (1000IU p.o. once daily for 5 days) has been shown to promote the chronic recovery of spinal-cord injured cats [45]. This is consistent with its ability to prevent post-traumatic spinal-cord hypoperfusion [29] and lipid peroxidation [8] and with the hypothesis that oxygen-radical generation and lipid peroxidation are important mediators of post-traumatic spinal-cord pathophysiology and degeneration. 

Recent studies suggest that U-74006F retains its efficacy in promoting post-traumatic recovery after experimental spinal-cord injury even when initiation of treatment is delayed to 4 hours post-injury. However, after a treatment delay 

TIRILAZAD MESYLATE IN CAT SPINAL CORD COMPRESSION INJURY 

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