Effect of surfactants on membrane permeability

The end point in the experiment is the turnover time or death time of the fish. 

The reciprocal death time (T ) is proportional to the rate of absorption of the drug, /cj 

In some systems where the drug concerned interacts to a small degree with a surfactant which has a significant effect on permeability, only the increase in absorption is detectable. This is the case with thiopentone and a series of non- 

There are several competing mechanisms for surfactant-induced effects when solid oral dosage forms are administered. When solutions are administered. 

There is no simple explanation of the absorption-promoting effect of the surfactant. Penetration of the surfactant into the liquid membrane seems to be 

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The reported effects of surfactants on membrane permeability have been observed by other authors using a different approach. Rege et al. [32] studied the inhibition activity of non-ionic surfactants on P-glycoprotein (P-gp) efflux and the relationship between inhibition and membrane fluidity. Tween 80 and Cremophor inhibited P-gp. These inhibition effects could be related to their effects on membrane fluidity, as these surfactants fluidized cell lipid bilayers. This fluidification mechanism could be related to the increase in membrane polarity that we observed with synthetic surfactants in our experiments and it has been reported by other authors as a possible explanation for the inhibition effects of surfactants on P-gp efflux in the blood-brain barrier [33]. 

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