Editing opening sequence

Load the configuration file dsweep.cfg. Open the spin system file (Edit Spin system...) and note the spin system variable definition. Examine the pulse sequence (Edit Pulse program...) and note the additional loop command to increment the chemical shift. Using the GolRun Experiment command simulate the spectrum which corresponds to the excitation profile of a 90° TOPHAT pulse. In 1D WIN-NMR process the FID using zero filling of Sl(r+i) 32/cand an exponential window function with a LB value of 2 Hz. 

Using the File I Pulse program... command load the pulse program cp121.seq into NMR-SIM. Open the file (Edit I Pulse program...) from c nmrsim session pp ppfrag and examine the text file for the execution commands sample, ihc and lo to. The pulse sequence is shown on the left-hand side of this Check it. 

Open the pulse program file ppexamO.seq using the Edit I Pulse program command. Add to the pulse sequence the loop label 3 in front of the command (p1 ph1) f1, append to the line wr 0 the increment instructions and... 

Load the configuration file ch53111.cfg. Open the pulse program editor (Edit I Pulse program) and change the template sequence into the NERO sequence shown below. Make sure to add the incrementation and loop commands to simulate the excitation profile using a proton with a variable... 

Ring expansion sequence of lactams by reaction with cyclic iminoethers followed by reductive ring opening to a macrocyclic lactam (see 1st edition). 

Essentially all of the reactions of interest involve the opening of the five-membered ring. Reductive cleavages of the N—O bond in isoxazolines and isoxazolidines have been known for many years, and were reported on in the first edition. One recent application was the conversion of a fused isoxazoline (33) to a /1-amino ketone <88TL5917>. An alternative sequence leading to these synthetically useful compounds first quaternized the N of a perhydro compound (34) and then reacted the product with a tertiary amine <88TL5949>. If the quaternary salt (35) was reacted with lithium iodide, a readily separable mixture of the ketone (36) and (+ )-allosedamine (37) resulted (Scheme 9) <89CB2019>. 

Open the spreadsheet 5-6.xls. Use the EDIT/MOVE OR COPY SHEET sequence to copy the twoell worksheet into the new file. This is the simplest way to ensure that the sequence of spreadsheet operations required for... 

Open fig2-7.xls and use the EDIT/MOVE OR COPY SHEET sequence to make three copies of the integration procedure. 

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